Case study

Reducing dropout by 53% and cutting study timelines by 14 months in a global gastroenterology study

23/03/2026
Patient and caregiver using Trial Flow on smart phones
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Key Results

53%

reduction in dropout rate

14 month

faster study delivery

100%

sponsor, CRO & site satisfaction

200+

users actively engaged

Background

Through our Trial Flow platform, Little Journey partnered with a global pharmaceutical sponsor and leading CRO to support a challenging gastroenterology study in erosive esophagitis. 

Study details: 68 patients enrolled | 35 sites | 9 countries | 16 languages

Challenges

Burdensome protocol

The study protocol included multiple endoscopies under general anaesthetic for an already approved drug, placing significant burden on patients and families. Maintaining motivation to continue participation was identified as a key operational risk.

High expected dropout rate

As a result of this burden, the anticipated dropout rate was high (75%), posing a significant risk to study timelines and data completeness.The sponsor required a scalable patient support solution to reduce dropout without increasing burden on site teams.

A cute looking cartoon mountain with a flag in the top.

Our solution

Trial Flow delivered a study-branded patient and caregiver support app focused on preparing families for procedures and guiding them through each visit. 

Key elements of the app configured for this protocol included:

  • Targeted, user-appropriate education to prepare patients and caregivers for endoscopies and anesthesia
  • Clear, structured guidance on what to expect at each stage of the study
  • Engaging content, including virtual tours, caregiver information, and distraction activities
Sample Trial Flow screens for this gastro study

Outcomes

Improved retention

53% reduction in dropout rate

 75% anticipated → 35% actual 

Faster delivery

14 month timeline reduction

October 2027 planned → August 2026 projected

High uptake

83% site uptake

29/35 sites, with 200+ cumulative app users

High satisfaction

100% would use again

With 75% of sites reporting it was easy to incorporate

speech marks

The visits to the sites by Little Journey were very valuable to helping the sites engage with the service and appreciate the value of implementing it.

Sponsor feedback

[Overview of the outcomes. Rearrange the cards below as needed!]

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